Have a blister? Annoying. Treat it wisely!
A friction blister is “a soft pocket of raised skin filled with clear fluid caused by irritation from continuous rubbing or pressure” . The most pressing concern (no pun intended) is infection. “[T]he skin provides a natural protection against infection” and thus “a blister should be left intact if possible” . In particular, “[d]o not drain the blister”! If the blister breaks naturally, do not remove the skin [2,3]; simply wash with soap and water, pat dry, apply antibacterial ointment, and cover with a bandage .
“[M]edical care is needed only if an infection develops. This is more likely to occur if the skin over the blister has been pierced, broken or popped” . If you observe signs of possible infection (intense tenderness, significant redness, warm skin, non-clear (e.g., white or yellow ) drainage, fever), then consult a doctor.